Patients fulfilling any of the following categories:

  • Transfusion dependent (four or more transfusions in 12 months)
  • Thrombosis related to PNH
  • Complications associated with haemolysis:
  1. Renal failure
  2. Pulmonary hypertension
  • Pregnancy (and for at least 3 months post-partum)
  • Haemolytic (LDH >1.5xULN) symptomatic PNH with either of the following
  1. With anaemia (Hb <9g/L) or
  2. With agreement with Joint Service colleagues at MDT
  • Exceptional cases in whom eculizumab is considered appropriate (not fulfilling the above criteria) will be approved through discussion between the 2 Nationally Commissioned PNH Services and the National Commissioners.